Solids NMR for Pharmaceutical Chemists

Many of the organic chemists at Ottawa U obtain employment with pharmaceutical companies after they graduate. Few of those graduates have any idea about what solid state NMR can do for the pharmaceutical industry. Here is an excellent review article written by a very well respected NMR spectroscopist (Robin Harris) on the applications of solid state NMR for the pharmaceutical industry.


Harris, Robin K.. Applications of solid-state NMR to pharmaceutical polymorphism and related matters. Journal of Pharmacy and Pharmacology (2007), 59(2), 225-239.

http://www.ingentaconnect.com/content/rpsgb/jpp/2007/00000059/00000002/art00009?token=004a11e57757e6f3f2f2730673f582f6b6d383a4b3b257b557b597a40386f3847415617d68

Online 1H and 13C NMR Database

There is an online database of 1H and 13C spectra which you may find useful. Take a look at it.

http://riodb01.ibase.aist.go.jp/sdbs/cgi-bin/direct_frame_top.cgi

Excellent On-line NMR Course

There is an excellent on-line NMR course designed by Francoise Sauriol of Queen's University available on the web at:

http://www.chem.queensu.ca/FACILITIES/NMR/nmr/webcourse/

Take a look at it.

NMR Chromatography

The DOSY (Diffusion Ordered Spectroscopy) experiment can be used to resolve the components of a mixture. The technique uses pulsed magnetic field gradients to resolve mixtures based on the different diffusion constants of the components of the mixture. The figure shows the resolution of a mixture of small molecules. The proton spectrum of the mixture is in the horizontal domain and the diffusion constants are in the vertical dimension.

Excellent NMR textbook

Many students have an understanding of the simple vector model to describe NMR experiments (if you don't you should take CHM 4380/8309B). The vector model can only explain the simplest of pulse sequences. To explain more complex sequences such as COSY, HMQC etc... one must resort to more involved models such as product operators. If you want to understand your NMR experiments I highly recommend the following book:

Understanding NMR Spectroscopy by James Keeler (Wiley, 2005)

You can also download notes from this book from the following web site:

http://www-keeler.ch.cam.ac.uk/

This is by far the best textbook I have seen on high resolution NMR spectroscopy since the early 1980's. It is written on a senior undergraduate level and very understandable.

NMR Facility Blog

I have created this blog to share useful NMR references, NMR news, interesting spectra and useful NMR information with the NMR users at the University of Ottawa. Feel free to comment on any of the posts.

Very good history of NMR recently published

Have you ever wanted to find the original references for NMR techniques? A very good review has recently been published in "Progress in Nuclear Magnetic Resonance Spectroscopy" which gives a detailed time line of the last 50 years of NMR with complete references. Check it out here:

http://scholarsportal.info/cgi-bin/sciserv.pl?collection=journals&journal=00796565&issue=v50i0004&article=179_fyopinmrs&form=fulltext